分離溴銨，也稱為YM155，是一種新的小分子存活抑制劑，是凋亡抑制基因家族的最小成員。它表現(xiàn)出對(duì)生存素的有效抑制活性，但對(duì)其他IAP家族成員或B細(xì)胞淋巴瘤2 (BCL-2)相關(guān)蛋白的表達(dá)水平幾乎沒有影響。YM155還抑制多種人類癌細(xì)胞系的增殖，在非小細(xì)胞肺癌(NSCLC)、黑色素瘤、膀胱、侵襲性非霍奇金淋巴瘤和乳腺癌異種移植模型中誘導(dǎo)腫瘤消退，減少自發(fā)轉(zhuǎn)移，并顯著延長具有源自人類三陰性乳腺癌(TNBC)細(xì)胞系的已確定轉(zhuǎn)移腫瘤的動(dòng)物的存活。

產(chǎn)品性質(zhì)：

Cas No.:781661-94-7

別名:4,9-二氫-1-(2-甲氧基乙基)-2-甲基-4,9-二氧代-3-(2-吡嗪甲基)-1H-萘并[2,3-D]咪唑溴化物,Sepantronium bromide,YM-155

化學(xué)名: 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide

Canonical SMILES CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]

分子式:C20H19BrN4O3

分子量:443.3

溶解度:≥ 22.15 mg/mL in DMSO, ≥ 13.49 mg/mL in EtOH with ultrasonic, ≥ 96.2 mg/mL in Water with ultrasonic

儲(chǔ)存條件:Store at -20°C

注意事項(xiàng)：

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References:

[1].Naoki Kaneko, Kentaro Yamanaka, Aya Kita, Kenji Tabata, Takafumi Akabane, and Masamichi Mori. Synergistic antitumor activities of sepantronium bromide (YM155), a surviving suppressant, in combination with microtubule-targeting agents in triple-negative breast cancer cells. Biol Pharm Bull 2013.

[2].Yan-Fang Tao, Jun Lu, Xiao-Juan Du, Li-Chao Sun, Xuan Zhao, Liang Peng, Lan Cao, Pei-Fang Xiao, Li Pang, Dong Wu, Na Wang, Xing Feng, Yan-Hong Li, Jian Ni, Jian Wang and Jian Pan. Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells. BMC Cancer 2012, 12:619