Ac-LEVD-CHO是一種胱天蛋白酶-4抑制劑。[1]當(dāng)使用濃度為30 μM時，它抑制人牙齦成纖維細(xì)胞中由齒垢分枝桿菌牙周病原體表面蛋白Td92誘導(dǎo)的IL-1α表達(dá)和分泌以及胱天蛋白酶-4激活。Ac-LEVD-CHO (10微米)還減少A549和PC3癌細(xì)胞中顯性陰性腺病毒RNA依賴蛋白激酶(Ad-δ6PKR)表達(dá)誘導(dǎo)的凋亡。[2]

產(chǎn)品性質(zhì)：

別名：Ac-Leu-Glu-Val-Asp-CHO, Caspase-4 Inhibitor I

化學(xué)名：N-acetyl-L-leucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-valinamide, trifluoroacetate salt

Canonical SMILES： CC(C)[C@@H](C(N[C@H](C=O)CC(O)=O)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)=O.FC(F)(C(O)=O)F

分子式：C22H36N4O9 ? XCF3COOH

分子量：500.5

溶解度：1mg/mL in formic acid

儲存條件：Store at -20°C

注意事項：

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References:

[1]. Jun, H.-K., Jung, Y.-J., An, S.-J., et al. Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts. Cell Death Differ. 25(2), 380-391 (2018).

[2]. Pataer, A., Swisher, S.G., Roth, J.A., et al. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol. Ther. 8(3), 245-252 (2009).