產品簡介：

    Ac-IETD-CHO是胱天蛋白酶-8的抑制劑(IC50 = 5 nM)。[1]當以60 μM的濃度使用時，它抑制丙酸氟替卡松誘導的哮喘患者外周血T細胞凋亡增加。[2] Ac-IETD-CHO (10 mg/kg)抑制Fas誘導的凋亡和肝衰竭小鼠模型中肝臟胱天蛋白酶-3活性、DNA片段化、胞質細胞色素c水平和胱天蛋白酶-3、-8和-9酶原蛋白水解加工的增加。[3]

產品性質：

別名:Caspase-8 Inhibitor

化學名:N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-threoninamide, trifluoroacetate salt

Canonical SMILES: C[C@@H](O)[C@@H](C(N[C@@H](CC(O)=O)C=O)=O)NC([C@@H](NC([C@H]([C@@H](C)CC)NC(C)=O)=O)CCC(O)=O)=O.FC(F)(C(O)=O)F

分子式:C21H34N4O10 ? XCF3COOH

分子量:502.5

溶解度:1mg/mL in water

儲存條件:Store at -20°C

注意事項：

為了您的安全和健康，請穿實驗服并戴一次性手套操作。

References:

[1]. Smith, G.K., Barrett, D.G., Blackburn, K.J., et al. Expression, preparation, and high-throughput screening of caspase-8: Discovery of redox-based and steroid diacid inhibition. Arch. Biochem. Biophys. 399(2), 195-205 (2002).

[2]. Pace, E., Gagliardo, R., Melis, M., et al. Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma. J. Allergy. Clin. Immunol. 114(5), 1216-1223 (2004).

[3]. Bajt, M.L., Lawson, J.A., Vonderfecht, S.L., et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: Evidence for a postmitochondrial processing of caspase-8. Toxicol. Sci. 58(1), 109-117 (2000)