Batimastat(也稱為BB-49)，[4-(N-羥基氨基)-2R-異丁基-3S-(硫代戊環(huán)-2-基硫代甲基)-琥珀酰-L-苯丙氨酸-N-甲基酰胺]是廣譜基質(zhì)金屬蛋白酶(MMPs)的有效合成抑制劑，所述基質(zhì)金屬蛋白酶包括間質(zhì)膠原酶(IC50 = 3 nM)、基質(zhì)分解素(IC50 = 20 nM)、Mr 72，000 IV型膠原酶(IC50 = 4 nM)、Mr 92，000 IV型膠原酶(IC50 = 4 nM)它是一種低分子量(MW = 478)和肽樣膠原底物類似物，由分別結(jié)合MMPs和催化活性鋅原子的肽骨架和異羥肟酸基團(tuán)組成。Batimastat在各種腫瘤模型中顯示抗腫瘤和抗血管生成活性，包括卵巢癌移植物和人結(jié)腸腫瘤。

產(chǎn)品性質(zhì)：

Cas No.:130370-60-4

別名:巴馬司他; BB94

化學(xué)名: (2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-2-((thiophen-2-ylthio)methyl)succinamide

Canonical SMILES:CNC([C@@H](NC([C@@H]([C@H](CSC1=CC=CS1)C(NO)=O)CC(C)C)=O)CC2=CC=CC=C2)=O

分子式:C23H31N3O4S2

分子量:477.64

溶解度:≥ 23.88mg/mL in DMSO

儲存條件:Store at 4°C

注意事項：

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References:

[1].Bernard Davies, Peter D. Brown, Nick East, Michael J. Crimmin, and Frances R. Balkwill. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Research 1993; 53: 2087-2091

[2].X. Wang, X. Fu, P.D. Brown, M. J. Crimmin, and R. M. Hoffman. Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Research 1994; 54: 4726-4728

[3].Raffaella Giavazzi, Angela Garofalo, Cristina Ferri, Valeria Lucchini, Elisabeth A. Bone, Stefania Chiari, Peter D. Brown, M. Ines Nicoletti, and Giulia Taraboletti. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xgenografts. Clinical Cancer Research 1998; 4: 985-992