干細(xì)胞生成素1 (SR1)是一種嘌呤衍生物，是芳香烴受體(AhR)的有效小分子抑制劑，其在CD34+細(xì)胞中以127 nM的50%抑制濃度IC50值有效拮抗AhR。已經(jīng)發(fā)現(xiàn)SR1促進(jìn)CD34+細(xì)胞的體外擴(kuò)增。最近的研究結(jié)果表明，用SR1培養(yǎng)造血干細(xì)胞(HSC)使表達(dá)CD34的細(xì)胞增加了50倍，使保留移植免疫缺陷小鼠能力的細(xì)胞增加了17倍。還發(fā)現(xiàn)SR1誘導(dǎo)PDC、BDCA1+和bdca 3+MDC的離體分化以及所有這些DC亞群的大量產(chǎn)生。

產(chǎn)品性質(zhì)：

Cas No.:1227633-49-9

別名:SR1

化學(xué)名:4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol

Canonical SMILES:CC(C)N1C=NC2=C1N=C(N=C2NCCC3=CC=C(C=C3)O)C4=CSC5=CC=CC=C54

分子式:C24H23N5OS

分子量:429.54

溶解度:≥ 21.5mg/mL in DMSO, ≥ 3.41 mg/mL in EtOH with ultrasonic

儲(chǔ)存條件:Store at -20°C

注意事項(xiàng)：

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References:

[1].Thordardottir S, Hangalapura BN, Hutten T, Cossu M, Spanholtz J, Schaap N, Radstake TR, Vandervoort R, Dolstra H. The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. Stem Cells Dev. 2013 Dec 10. [Epub ahead of print]

[2].Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10;329(5997):1345-8. doi: 10.1126/science.1191536. Epub 2010 Aug 5.