乳孢素是一種從鏈霉菌中分離出的微生物代謝產(chǎn)物，現(xiàn)已廣泛用作20S蛋白酶體的選擇性抑制劑[1],[2],[3]。乳孢素首先通過其在幾種腫瘤細胞系中誘導分化和抑制細胞周期進展的能力而被表征。在2到10微米的濃度下，乳孢素能夠誘導神經(jīng)母細胞瘤細胞系Neuro2a的神經(jīng)突起的生長[4]。乳孢素不可逆地烷基化20S蛋白酶體的X亞基。蛋白酶體肽酶活性的共同抑制導致各種泛素化蛋白的積累，這些蛋白本應快速降解。因此，乳孢素的效應是多樣的，且在所處理的細胞中的信號蛋白的表達模式中具有重要的依賴性。

產(chǎn)品性質(zhì)：

Cas No.:133343-34-7

別名:蛋白酶體抑制劑,乳孢素

化學名: 2-acetamido-3-[3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid

Canonical SMILES:CC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O

分子式:C15H24N2O7S

分子量:376.42

溶解度:1mg/mL in ethanol, 20mg/mL in DMSO, or in DMF

儲存條件:Store at -20°C

注意事項：

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References:

[1]. Omura, S., Fujimoto, T.T., Otoguro, K., et al. Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. Journal of Antibiotics 44, 113-116 (1991).

[2]. Corey, E.J., and Reichard, G.A. Total synthesis of lactacystin. Journal of the American Chemical Society 114, 10677-10678 (1992).

[3]. Fenteany, G., and Schreiber, S.L. Lactacystin, proteasome function, and cell fate. The Journal of Biological Chemisty 273(15), 8545-8548 (1998).

[4]. Fenteany, G., Standaert, R.F., Reichard, G.A., et al. A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proceedings of the National Academy of Sciences of the United States of America 91, 3358-3362 (1994).