Garcinol是組蛋白乙酰轉(zhuǎn)移酶(HATs) p300和PCAF (IC50分別為7和5微米)的抑制劑。[1]它還抑制新生隱球菌中的HAT GCN5，誘導(dǎo)溫度敏感性并損害生長。[2]藤黃醇是一種分離自藤黃的聚異戊二烯化二苯甲酮，可促進(jìn)人類造血干細(xì)胞的神經(jīng)發(fā)生和體外擴(kuò)增。[3]，[4]此外，它在幾種類型的癌細(xì)胞中誘導(dǎo)凋亡并具有抗炎作用。[5],[6]

產(chǎn)品性質(zhì)：

Cas No.:78824-30-3

別名：山竹子素

化學(xué)名: (1R,5R,7R)-3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-((S)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione

Canonical SMILES: O=C1[C@](C(O)=C2C(C3=CC(O)=C(O)C=C3)=O)(C[C@H](C/C=C(C)/C)C(C)=C)C[C@@H](C/C=C(C)/C)C(C)(C)[C@@]1(C/C=C(C)/C)C2=O

分子式:C38H50O6

分子量:602.8

溶解度:20mg/mL in ethanol, 25mg/mL in DMSO, 25mg/mL in DMF

儲(chǔ)存條件:Store at -20°C,protect from light

注意事項(xiàng)：

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References:

[1]. Balasubramanyam, K., Altaf, M., Varier, R.A., et al. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. The Journal of Biological Chemisty 279(6), 33716-33726 (2004).

[2]. O'Meara, T.R., Hay, C., Price, M.S., et al. Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. Eukaryot.Cell 9(8), 1193-1202 (2010).

[3]. Weng, M.S., Liao, C.H., Yu, S.Y., et al. Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. Journal of Agricultural and Food Chemistry 59, 1031-1040 (2011).

[4]. Nishino, T., Wang, C., Mochizuki-Kashio, M., et al. Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One 6(9), 1-9 (2011).

[5]. Prasad, S., Ravindran, J., Sung, B., et al. Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins. Molecular Cancer Therapeutics 9(4), 856-868 (2010).

[6]. Koeberle, A., Northoff, H., and Werz, O. Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. Biochemical Pharmacology 77(9), 1513-1521 (2009).