ITF2357，也稱為givinostat，是I類和II類組蛋白脫乙酰酶(HDAC)的有效抑制劑，也是體外慢性骨髓增生性腫瘤中攜帶JAKEV617F的祖細(xì)胞造血集落形成的有效抑制劑。先前的研究表明，ITF2357在誘導(dǎo)p21和下調(diào)Bcl-2和Mcl-1蛋白后誘導(dǎo)多發(fā)性骨髓瘤(MM)和急性髓性白血病(AML)細(xì)胞凋亡，并抑制外周血單核細(xì)胞產(chǎn)生促炎細(xì)胞因子(如IL-1、IL-6、腫瘤壞死因子(TNF)-α和干擾素(IFN)-γ)以及間充質(zhì)基質(zhì)細(xì)胞產(chǎn)生IL-6和血管內(nèi)皮生長(zhǎng)因子(VEGF)。

產(chǎn)品性質(zhì)：

Cas No.:732302-99-7

別名:N-[4-[(羥基氨基)羰基]苯基]氨基甲酸[6-[(二乙基氨基)甲基]-2-萘基]甲酯鹽酸鹽水合物,ITF-2357, Givinostat (hydrochloride monohydrate)

化學(xué)名:(6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride hydrate

Canonical SMILES:CCN(CC)CC1=CC2=C(C=C(COC(NC3=CC=C(C(NO)=O)C=C3)=O)C=C2)C=C1.O.Cl

分子式:C24H27N3O4.HCl.H2O

分子量；475.97

溶解度：≥ 23.8 mg/mL in DMSO, ≥ 2.9 mg/mL in Water with ultrasonic and warming

儲(chǔ)存條件;Store at -20°C

注意事項(xiàng)：

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Reference:

 [1].Katia Todoerti, Valentina Barbui, Olga Pedrini, Marta Linett, Gianluca Fossati, Paolo Mascagni, Alessandro Rambaldi, Antonino Neri, Martino Introna, Luigia Lombardi, and Josee Golay. Pleiotropi anti-myeloma activity of ITF2357: inhibition of interleukin-6 receptor signaling and repression of miR-19a and miR-19b. Haematologica 2010; 95(2): 260-269